Drug interactions
Ciprofloxacin + Glecaprevir / pibrentasvir
Severity: Minor
Ciprofloxacin and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit intestinal P-glycoprotein and could increase ciprofloxacin absorption. Ciprofloxacin is only a modest P-gp substrate, so any rise in exposure is expected to be small and clinically minor.
What this interaction means in plain words
Ciprofloxacin and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of P-glycoprotein efflux by glecaprevir/pibrentasvir, theoretically increasing ciprofloxacin bioavailability.
What to do
No dose change is usually needed; be aware of possible increased ciprofloxacin adverse effects such as gastrointestinal upset or CNS effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Ciprofloxacin and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit intestinal P-glycoprotein and could increase ciprofloxacin absorption. Ciprofloxacin is only a modest P-gp substrate, so any rise in exposure is expected to be small and clinically minor.
How serious is the interaction between Ciprofloxacin and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; be aware of possible increased ciprofloxacin adverse effects such as gastrointestinal upset or CNS effects.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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