Drug interactions
Ciprofloxacin + Ketorolac
Severity: Moderate
Ciprofloxacin and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may lower the seizure threshold and, in combination with fluoroquinolones, can increase the risk of CNS stimulation and convulsions. The risk is highest with high fluoroquinolone doses, renal impairment or a seizure history.
What this interaction means in plain words
Ciprofloxacin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Ketorolac belongs to Musculoskeletal.
Why it happens
Fluoroquinolone inhibition of GABA-A receptor binding may be potentiated by NSAIDs, lowering seizure threshold.
What to do
Avoid the combination in patients with epilepsy or other seizure risk factors; otherwise use the lowest effective doses and watch for tremor, agitation or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Ketorolac?
MediHelp rates the interaction as moderate. Ciprofloxacin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may lower the seizure threshold and, in combination with fluoroquinolones, can increase the risk of CNS stimulation and convulsions. The risk is highest with high fluoroquinolone doses, renal impairment or a seizure history.
How serious is the interaction between Ciprofloxacin and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with epilepsy or other seizure risk factors; otherwise use the lowest effective doses and watch for tremor, agitation or seizures.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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