Drug interactions
Ciprofloxacin + Mestranol
Severity: Minor
Ciprofloxacin and Mestranol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin has not been shown to lower oral contraceptive hormone levels or to cause ovulation breakthrough in studies. The suspected effect via gut flora is theoretical and the risk of contraceptive failure is very low.
What this interaction means in plain words
Ciprofloxacin and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of enterohepatic recycling of estrogen through altered gut flora; not established for ciprofloxacin.
What to do
No additional contraception is usually needed. Advise extra precautions if vomiting or diarrhoea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Mestranol?
MediHelp rates the interaction as minor. Ciprofloxacin and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ciprofloxacin has not been shown to lower oral contraceptive hormone levels or to cause ovulation breakthrough in studies. The suspected effect via gut flora is theoretical and the risk of contraceptive failure is very low.
How serious is the interaction between Ciprofloxacin and Mestranol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No additional contraception is usually needed. Advise extra precautions if vomiting or diarrhoea occurs.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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