Drug interactions
Ciprofloxacin + Mobocertinib
Severity: Major
Ciprofloxacin and Mobocertinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib has a boxed warning for QT prolongation and torsades de pointes, and ciprofloxacin adds to the effect. Ciprofloxacin may also modestly inhibit CYP3A, raising mobocertinib levels.
What this interaction means in plain words
Ciprofloxacin and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, with possible CYP3A inhibition increasing mobocertinib exposure.
What to do
Avoid combining; choose a non-QT-prolonging antibiotic. If unavoidable, reduce the mobocertinib dose per labeling and monitor ECGs and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ciprofloxacin and Mobocertinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
- Ciprofloxacin 250mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: drugs known to prolong QT interval; "drugs known to prolong QT interval") — electronic medicines compendium (UK SmPC)
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Mobocertinib?
MediHelp rates the interaction as major. Ciprofloxacin and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib has a boxed warning for QT prolongation and torsades de pointes, and ciprofloxacin adds to the effect. Ciprofloxacin may also modestly inhibit CYP3A, raising mobocertinib levels.
How serious is the interaction between Ciprofloxacin and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; choose a non-QT-prolonging antibiotic. If unavoidable, reduce the mobocertinib dose per labeling and monitor ECGs and electrolytes closely.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
