Drug interactions
Ciprofloxacin + Olaparib
Severity: Moderate
Ciprofloxacin and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin may inhibit CYP3A4 and raise olaparib concentrations, increasing the risk of anemia, nausea and other adverse effects. The effect is probably modest, as ciprofloxacin is a weak to moderate inhibitor.
What this interaction means in plain words
Ciprofloxacin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Olaparib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated olaparib metabolism.
What to do
Monitor blood counts and tolerability. Reduce the olaparib dose per labeling for moderate CYP3A inhibitors if the combination cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Ciprofloxacin with Olaparib?
MediHelp rates the interaction as moderate. Ciprofloxacin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin may inhibit CYP3A4 and raise olaparib concentrations, increasing the risk of anemia, nausea and other adverse effects. The effect is probably modest, as ciprofloxacin is a weak to moderate inhibitor.
How serious is the interaction between Ciprofloxacin and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and tolerability. Reduce the olaparib dose per labeling for moderate CYP3A inhibitors if the combination cannot be avoided.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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