Drug interactions
Ciprofloxacin + Quazepam
Severity: Minor
Ciprofloxacin and Quazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin may modestly raise exposure to quazepam and its active metabolites, which could increase sedation and psychomotor impairment. The effect is expected to be small and is inferred from the effect of ciprofloxacin on other benzodiazepines.
What this interaction means in plain words
Ciprofloxacin and Quazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ciprofloxacin inhibits CYP1A2 and may weakly reduce the hepatic metabolism of quazepam.
What to do
Watch for excess sedation or next-day impairment when starting ciprofloxacin in a patient taking quazepam. Reduce the quazepam dose if drowsiness develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Quazepam?
MediHelp rates the interaction as minor. Ciprofloxacin and Quazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ciprofloxacin may modestly raise exposure to quazepam and its active metabolites, which could increase sedation and psychomotor impairment. The effect is expected to be small and is inferred from the effect of ciprofloxacin on other benzodiazepines.
How serious is the interaction between Ciprofloxacin and Quazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for excess sedation or next-day impairment when starting ciprofloxacin in a patient taking quazepam. Reduce the quazepam dose if drowsiness develops.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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