Drug interactions
Ciprofloxacin + Typhoid vaccine live
Severity: Moderate
Ciprofloxacin and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin is active against Salmonella Typhi and can reduce replication of the live oral typhoid vaccine strain. This may lead to inadequate immunity.
What this interaction means in plain words
Ciprofloxacin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces its viability.
What to do
Give oral live typhoid vaccine at least 3 days after the last ciprofloxacin dose, or use the inactivated injectable vaccine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ciprofloxacin and Typhoid vaccine live, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Ciprofloxacin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin is active against Salmonella Typhi and can reduce replication of the live oral typhoid vaccine strain. This may lead to inadequate immunity.
How serious is the interaction between Ciprofloxacin and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral live typhoid vaccine at least 3 days after the last ciprofloxacin dose, or use the inactivated injectable vaccine.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
