Drug interactions
Ciprofloxacin + Zolpidem
Severity: Moderate
Ciprofloxacin and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin may raise zolpidem concentrations, increasing sedation, next-day impairment and complex sleep behaviors. Quinolones can also cause CNS effects, adding to the burden.
What this interaction means in plain words
Ciprofloxacin and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Zolpidem belongs to Central Nervous System.
Why it happens
Ciprofloxacin inhibits CYP1A2 and weakly CYP3A4, which contribute to zolpidem metabolism.
What to do
Monitor for excessive sedation and consider a lower zolpidem dose during ciprofloxacin therapy. Advise against driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Zolpidem
Frequently asked questions
Can I take Ciprofloxacin with Zolpidem?
MediHelp rates the interaction as moderate. Ciprofloxacin and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin may raise zolpidem concentrations, increasing sedation, next-day impairment and complex sleep behaviors. Quinolones can also cause CNS effects, adding to the burden.
How serious is the interaction between Ciprofloxacin and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider a lower zolpidem dose during ciprofloxacin therapy. Advise against driving if drowsy.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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