Drug interactions
Cisatracurium + Cortisone
Severity: Moderate
Cisatracurium and Cortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as cortisone given with nondepolarizing neuromuscular blockers have been associated with acute myopathy, particularly in critically ill patients receiving prolonged blockade. This can present as persistent weakness and delayed ventilator weaning.
What this interaction means in plain words
Cisatracurium and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid-related muscle protein breakdown combined with prolonged neuromuscular blockade is thought to contribute to myopathy; the mechanism is not fully defined.
What to do
Limit the dose and duration of cisatracurium and monitor depth of blockade with train-of-four. Evaluate promptly for weakness and check creatine kinase if myopathy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Cortisone?
MediHelp rates the interaction as moderate. Cisatracurium and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as cortisone given with nondepolarizing neuromuscular blockers have been associated with acute myopathy, particularly in critically ill patients receiving prolonged blockade. This can present as persistent weakness and delayed ventilator weaning.
How serious is the interaction between Cisatracurium and Cortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the dose and duration of cisatracurium and monitor depth of blockade with train-of-four. Evaluate promptly for weakness and check creatine kinase if myopathy is suspected.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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