Drug interactions
Cisatracurium + Diltiazem
Severity: Minor
Cisatracurium and Diltiazem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may modestly enhance and prolong neuromuscular blockade from nondepolarizing agents such as cisatracurium. The effect is usually small, but recovery may be slower than expected.
What this interaction means in plain words
Cisatracurium and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cisatracurium belongs to Musculoskeletal; Diltiazem belongs to Cardiovascular.
Why it happens
Calcium channel blockade may reduce presynaptic acetylcholine release and add to postsynaptic nondepolarizing blockade.
What to do
Monitor neuromuscular function with train-of-four and titrate cisatracurium to effect. Be prepared for slower recovery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisatracurium
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Cisatracurium with Diltiazem?
MediHelp rates the interaction as minor. Cisatracurium and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers may modestly enhance and prolong neuromuscular blockade from nondepolarizing agents such as cisatracurium. The effect is usually small, but recovery may be slower than expected.
How serious is the interaction between Cisatracurium and Diltiazem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and titrate cisatracurium to effect. Be prepared for slower recovery.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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