Drug interactions
Cisatracurium + Fentanyl
Severity: Minor
Cisatracurium and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisatracurium is a neuromuscular blocker without sedative or analgesic action, so the interaction is largely a matter of context. In anesthesia, opioids and neuromuscular blockers are used together routinely under ventilatory control, and fentanyl may enhance bradycardia or hypotension but does not meaningfully potentiate the block.
What this interaction means in plain words
Cisatracurium and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cisatracurium belongs to Musculoskeletal; Fentanyl belongs to Musculoskeletal.
Why it happens
No significant pharmacokinetic interaction; effects are largely independent, with only minor additive hemodynamic effects.
What to do
No action beyond standard monitored use with ventilatory support in anesthesia; avoid use outside a monitored setting.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Fentanyl?
MediHelp rates the interaction as minor. Cisatracurium and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cisatracurium is a neuromuscular blocker without sedative or analgesic action, so the interaction is largely a matter of context. In anesthesia, opioids and neuromuscular blockers are used together routinely under ventilatory control, and fentanyl may enhance bradycardia or hypotension but does not meaningfully potentiate the block.
How serious is the interaction between Cisatracurium and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action beyond standard monitored use with ventilatory support in anesthesia; avoid use outside a monitored setting.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Full monographs, dosing and an interaction checker in the MediHelp app
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