Drug interactions
Cisatracurium + Isradipine
Severity: Minor
Cisatracurium and Isradipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may enhance and prolong neuromuscular blockade from non-depolarizing agents. The effect with isradipine and cisatracurium is probably small but may delay recovery.
What this interaction means in plain words
Cisatracurium and Isradipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Calcium channel blockade reduces presynaptic acetylcholine release, adding to cisatracurium blockade.
What to do
Monitor neuromuscular function with train-of-four and dose cisatracurium to effect. Allow for slower recovery before extubation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Isradipine?
MediHelp rates the interaction as minor. Cisatracurium and Isradipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers may enhance and prolong neuromuscular blockade from non-depolarizing agents. The effect with isradipine and cisatracurium is probably small but may delay recovery.
How serious is the interaction between Cisatracurium and Isradipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and dose cisatracurium to effect. Allow for slower recovery before extubation.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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