Drug interactions
Cisatracurium + Magnesium sulfate
Severity: Moderate
Cisatracurium and Magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parenteral magnesium sulfate potentiates nondepolarizing neuromuscular blockade, producing a deeper and longer block than expected. This can delay recovery and cause residual paralysis and respiratory depression.
What this interaction means in plain words
Cisatracurium and Magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Magnesium reduces presynaptic acetylcholine release and decreases postsynaptic sensitivity, adding to competitive blockade.
What to do
Reduce the cisatracurium dose and monitor with train-of-four, confirming full recovery before extubation. Monitor serum magnesium and respiratory function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Magnesium sulfate?
MediHelp rates the interaction as moderate. Cisatracurium and Magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral magnesium sulfate potentiates nondepolarizing neuromuscular blockade, producing a deeper and longer block than expected. This can delay recovery and cause residual paralysis and respiratory depression.
How serious is the interaction between Cisatracurium and Magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the cisatracurium dose and monitor with train-of-four, confirming full recovery before extubation. Monitor serum magnesium and respiratory function.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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