Drug interactions
Cisatracurium + Neomycin po
Severity: Major
Cisatracurium and Neomycin po: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed but can reach systemic levels with impaired renal function, damaged gut mucosa or large doses, and aminoglycosides can intensify neuromuscular blockade. This may cause prolonged paralysis or apnea.
What this interaction means in plain words
Cisatracurium and Neomycin po can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Aminoglycosides reduce presynaptic acetylcholine release and postsynaptic sensitivity, adding to nondepolarizing blockade.
What to do
Monitor neuromuscular function and assess renal function and bowel integrity. Reduce cisatracurium dosing and maintain ventilatory support until full recovery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cisatracurium and Neomycin po, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Neomycin po?
MediHelp rates the interaction as major. Cisatracurium and Neomycin po can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral neomycin is poorly absorbed but can reach systemic levels with impaired renal function, damaged gut mucosa or large doses, and aminoglycosides can intensify neuromuscular blockade. This may cause prolonged paralysis or apnea.
How serious is the interaction between Cisatracurium and Neomycin po?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function and assess renal function and bowel integrity. Reduce cisatracurium dosing and maintain ventilatory support until full recovery.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
