Drug interactions
Cisatracurium + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Minor
Cisatracurium and Sodium sulfate / ?magnesium sulfate / potassium chloride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral bowel-prep products containing magnesium are minimally absorbed, so systemic magnesium effects are unlikely in patients with normal renal function. Significant potentiation of neuromuscular blockade would mainly be a concern with hypermagnesemia, for example in renal impairment.
What this interaction means in plain words
Cisatracurium and Sodium sulfate / ?magnesium sulfate / potassium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Magnesium reduces presynaptic acetylcholine release and postsynaptic sensitivity, enhancing nondepolarizing blockade if serum levels become elevated.
What to do
No routine action in normal renal function. Check serum magnesium and use neuromuscular monitoring if the patient has renal impairment or electrolyte disturbance after bowel preparation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as minor. Cisatracurium and Sodium sulfate / ?magnesium sulfate / potassium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral bowel-prep products containing magnesium are minimally absorbed, so systemic magnesium effects are unlikely in patients with normal renal function. Significant potentiation of neuromuscular blockade would mainly be a concern with hypermagnesemia, for example in renal impairment.
How serious is the interaction between Cisatracurium and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action in normal renal function. Check serum magnesium and use neuromuscular monitoring if the patient has renal impairment or electrolyte disturbance after bowel preparation.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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