Drug interactions
Cisatracurium + Tobramycin inhaled
Severity: Minor
Cisatracurium and Tobramycin inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can potentiate non-depolarizing neuromuscular blockade. With inhaled tobramycin systemic exposure is low, so the effect is usually small, but it may be relevant with renal impairment or high doses.
What this interaction means in plain words
Cisatracurium and Tobramycin inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aminoglycosides reduce presynaptic acetylcholine release and have a weak postsynaptic blocking effect, adding to cisatracurium.
What to do
Monitor neuromuscular function with train-of-four and titrate cisatracurium to effect. Take extra care in patients with renal impairment or myasthenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Tobramycin inhaled?
MediHelp rates the interaction as minor. Cisatracurium and Tobramycin inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aminoglycosides can potentiate non-depolarizing neuromuscular blockade. With inhaled tobramycin systemic exposure is low, so the effect is usually small, but it may be relevant with renal impairment or high doses.
How serious is the interaction between Cisatracurium and Tobramycin inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and titrate cisatracurium to effect. Take extra care in patients with renal impairment or myasthenia.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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