Drug interactions
Cisatracurium + Triamcinolone acetonide injectable
Severity: Moderate
Cisatracurium and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given with nondepolarizing neuromuscular blockers, particularly during prolonged ICU use, have been associated with acute myopathy. Weakness may delay recovery and weaning from ventilation. Risk with a single local triamcinolone injection is likely lower than with high-dose systemic steroids.
What this interaction means in plain words
Cisatracurium and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable additive myotoxicity; the exact mechanism is not fully established.
What to do
Avoid prolonged neuromuscular blockade where possible and use the lowest effective doses of both. Monitor for persistent weakness and creatine kinase if used long term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Cisatracurium and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with nondepolarizing neuromuscular blockers, particularly during prolonged ICU use, have been associated with acute myopathy. Weakness may delay recovery and weaning from ventilation. Risk with a single local triamcinolone injection is likely lower than with high-dose systemic steroids.
How serious is the interaction between Cisatracurium and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged neuromuscular blockade where possible and use the lowest effective doses of both. Monitor for persistent weakness and creatine kinase if used long term.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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