Drug interactions
Citalopram + Deutetrabenazine
Severity: Moderate
Citalopram and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, although deutetrabenazine does so only modestly at recommended doses. Risk of torsades de pointes is higher with bradycardia, electrolyte disturbances or additional QT-prolonging drugs.
What this interaction means in plain words
Citalopram and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Keep citalopram within its maximum labeled dose and monitor the QTc in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Citalopram with Deutetrabenazine?
MediHelp rates the interaction as moderate. Citalopram and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, although deutetrabenazine does so only modestly at recommended doses. Risk of torsades de pointes is higher with bradycardia, electrolyte disturbances or additional QT-prolonging drugs.
How serious is the interaction between Citalopram and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Keep citalopram within its maximum labeled dose and monitor the QTc in at-risk patients.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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