Drug interactions
Citalopram + Duvelisib
Severity: Minor
Citalopram and Duvelisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4, which contributes to citalopram metabolism, so citalopram exposure may increase modestly. Higher levels raise the risk of dose-related adverse effects including QT prolongation.
What this interaction means in plain words
Citalopram and Duvelisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4-mediated citalopram metabolism.
What to do
Monitor for increased citalopram adverse effects and consider an ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Citalopram with Duvelisib?
MediHelp rates the interaction as minor. Citalopram and Duvelisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duvelisib inhibits CYP3A4, which contributes to citalopram metabolism, so citalopram exposure may increase modestly. Higher levels raise the risk of dose-related adverse effects including QT prolongation.
How serious is the interaction between Citalopram and Duvelisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased citalopram adverse effects and consider an ECG in patients with cardiac risk factors.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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