Drug interactions
Citalopram + Etodolac
Severity: Moderate
Citalopram and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with an SSRI increases the risk of upper gastrointestinal bleeding beyond that of either drug alone. The risk is greater in older patients and those with prior ulcers.
What this interaction means in plain words
Citalopram and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Etodolac belongs to Musculoskeletal.
Why it happens
SSRIs deplete platelet serotonin impairing aggregation while NSAIDs inhibit platelet thromboxane and damage gastric mucosa, giving additive bleeding risk.
What to do
Avoid the combination where possible; if needed, consider gastroprotection with a proton pump inhibitor and monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Etodolac?
MediHelp rates the interaction as moderate. Citalopram and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with an SSRI increases the risk of upper gastrointestinal bleeding beyond that of either drug alone. The risk is greater in older patients and those with prior ulcers.
How serious is the interaction between Citalopram and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, consider gastroprotection with a proton pump inhibitor and monitor for signs of GI bleeding.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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