Drug interactions
Citalopram + Histrelin
Severity: Moderate
Citalopram and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, causes androgen deprivation that can prolong the QT interval, and citalopram also prolongs QT. The combination may increase the risk of torsades de pointes.
What this interaction means in plain words
Citalopram and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation, with androgen deprivation therapy affecting cardiac repolarization.
What to do
Obtain a baseline ECG and electrolytes and monitor periodically, using the lowest effective citalopram dose. Consider an alternative antidepressant in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Citalopram with Histrelin?
MediHelp rates the interaction as moderate. Citalopram and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, causes androgen deprivation that can prolong the QT interval, and citalopram also prolongs QT. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Citalopram and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and monitor periodically, using the lowest effective citalopram dose. Consider an alternative antidepressant in patients with other QT risk factors.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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