Drug interactions
Citalopram + Hydrochlorothiazide-losartan
Severity: Moderate
Citalopram and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazides and SSRIs such as citalopram can cause hyponatremia, so the combination increases this risk, especially in older adults. Thiazide-related hypokalemia or hypomagnesemia may also add to citalopram's QT prolongation.
What this interaction means in plain words
Citalopram and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive SIADH-like and diuretic-induced sodium loss, with electrolyte disturbances increasing QT risk.
What to do
Check sodium, potassium and magnesium at baseline and after initiation, and monitor for confusion or falls. Correct electrolytes and keep citalopram within recommended dose limits, especially in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Citalopram and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazides and SSRIs such as citalopram can cause hyponatremia, so the combination increases this risk, especially in older adults. Thiazide-related hypokalemia or hypomagnesemia may also add to citalopram's QT prolongation.
How serious is the interaction between Citalopram and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sodium, potassium and magnesium at baseline and after initiation, and monitor for confusion or falls. Correct electrolytes and keep citalopram within recommended dose limits, especially in elderly patients.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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