Drug interactions
Citalopram + Lenacapavir
Severity: Minor
Citalopram and Lenacapavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir moderately inhibits CYP3A4 and may increase citalopram concentrations, an effect that can persist for months after subcutaneous dosing. Higher citalopram exposure may increase dose-related adverse effects including QT prolongation.
What this interaction means in plain words
Citalopram and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
Moderate CYP3A4 inhibition reduces citalopram metabolism.
What to do
Monitor for citalopram adverse effects and consider ECG in patients with cardiac risk factors. Adjust dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Citalopram with Lenacapavir?
MediHelp rates the interaction as minor. Citalopram and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir moderately inhibits CYP3A4 and may increase citalopram concentrations, an effect that can persist for months after subcutaneous dosing. Higher citalopram exposure may increase dose-related adverse effects including QT prolongation.
How serious is the interaction between Citalopram and Lenacapavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for citalopram adverse effects and consider ECG in patients with cardiac risk factors. Adjust dose if needed.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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