Drug interactions
Flibanserin + Lenacapavir
Severity: Contraindicated
Flibanserin and Lenacapavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may increase flibanserin exposure. Elevated flibanserin levels raise the risk of hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Lenacapavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Flibanserin belongs to Genitourinary; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 reduces flibanserin clearance.
What to do
Avoid the combination in line with the flibanserin restriction on moderate CYP3A4 inhibitors.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
- Amobarbital + Lenacapavir Major
Frequently asked questions
Can I take Flibanserin with Lenacapavir?
MediHelp rates the interaction as contraindicated. Flibanserin and Lenacapavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lenacapavir is a moderate CYP3A inhibitor and may increase flibanserin exposure. Elevated flibanserin levels raise the risk of hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Lenacapavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in line with the flibanserin restriction on moderate CYP3A4 inhibitors.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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