Drug interactions
Citalopram + Naratriptan
Severity: Moderate
Citalopram and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs combined with triptans have been associated with serotonin syndrome in case reports, although the absolute risk appears low. Symptoms include agitation, tremor, sweating, diarrhea and hyperthermia.
What this interaction means in plain words
Citalopram and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effect (5-HT1B/1D agonism plus serotonin reuptake inhibition); mechanism not firmly established.
What to do
The combination can be used when clinically needed; counsel the patient on serotonin syndrome symptoms. Monitor especially at initiation and dose increases, and stop the triptan if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Citalopram with Naratriptan?
MediHelp rates the interaction as moderate. Citalopram and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs combined with triptans have been associated with serotonin syndrome in case reports, although the absolute risk appears low. Symptoms include agitation, tremor, sweating, diarrhea and hyperthermia.
How serious is the interaction between Citalopram and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can be used when clinically needed; counsel the patient on serotonin syndrome symptoms. Monitor especially at initiation and dose increases, and stop the triptan if symptoms occur.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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