Drug interactions
Citalopram + Nicardipine
Severity: Minor
Citalopram and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly inhibit CYP3A4 and raise citalopram concentrations, though CYP2C19 is also important. Higher citalopram exposure carries a dose-related risk of QT prolongation.
What this interaction means in plain words
Citalopram and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by nicardipine reduces part of citalopram clearance.
What to do
No routine adjustment is needed; keep citalopram within recommended maximum doses. Consider ECG monitoring if other QT risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Nicardipine?
MediHelp rates the interaction as minor. Citalopram and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may modestly inhibit CYP3A4 and raise citalopram concentrations, though CYP2C19 is also important. Higher citalopram exposure carries a dose-related risk of QT prolongation.
How serious is the interaction between Citalopram and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; keep citalopram within recommended maximum doses. Consider ECG monitoring if other QT risk factors are present.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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