Drug interactions
Citalopram + Prasugrel
Severity: Moderate
Citalopram and Prasugrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs impair platelet serotonin uptake and aggregation, which adds to the antiplatelet effect of prasugrel. This increases the risk of bleeding, notably gastrointestinal bleeding.
What this interaction means in plain words
Citalopram and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Prasugrel belongs to Cardiovascular.
Why it happens
Additive impairment of platelet function (pharmacodynamic).
What to do
Monitor for signs of bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Avoid additional NSAIDs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Prasugrel
Frequently asked questions
Can I take Citalopram with Prasugrel?
MediHelp rates the interaction as moderate. Citalopram and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs impair platelet serotonin uptake and aggregation, which adds to the antiplatelet effect of prasugrel. This increases the risk of bleeding, notably gastrointestinal bleeding.
How serious is the interaction between Citalopram and Prasugrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Avoid additional NSAIDs.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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