Drug interactions
Citalopram + Ticagrelor
Severity: Moderate
Citalopram and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citalopram, an SSRI, reduces platelet serotonin content and can impair aggregation. With ticagrelor, the risk of bleeding, especially GI, is increased.
What this interaction means in plain words
Citalopram and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Ticagrelor belongs to Cardiovascular.
Why it happens
Additive platelet dysfunction from P2Y12 blockade and SSRI-mediated serotonin depletion in platelets.
What to do
Monitor for bleeding and consider a proton pump inhibitor in patients at high GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Ticagrelor?
MediHelp rates the interaction as moderate. Citalopram and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Citalopram, an SSRI, reduces platelet serotonin content and can impair aggregation. With ticagrelor, the risk of bleeding, especially GI, is increased.
How serious is the interaction between Citalopram and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider a proton pump inhibitor in patients at high GI risk.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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