Drug interactions
Citalopram + Umeclidinium-vilanterol
Severity: Moderate
Citalopram and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citalopram causes dose-dependent QT prolongation, and vilanterol may add beta-adrenergic cardiac effects including tachycardia and hypokalemia. The combination may increase the risk of arrhythmia, especially in patients with existing cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Citalopram and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta-agonist-induced cardiac stimulation and potential hypokalemia.
What to do
Keep citalopram at or below the labeled maximum dose and obtain an ECG in patients with cardiac risk factors. Monitor potassium and magnesium and watch for palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Citalopram and Umeclidinium-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Umeclidinium-vilanterol
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Citalopram and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Citalopram causes dose-dependent QT prolongation, and vilanterol may add beta-adrenergic cardiac effects including tachycardia and hypokalemia. The combination may increase the risk of arrhythmia, especially in patients with existing cardiac disease or electrolyte disturbances.
How serious is the interaction between Citalopram and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep citalopram at or below the labeled maximum dose and obtain an ECG in patients with cardiac risk factors. Monitor potassium and magnesium and watch for palpitations.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
