Drug interactions
Citalopram + Vonoprazan
Severity: Minor
Citalopram and Vonoprazan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan may weakly inhibit CYP2C19, one of the main enzymes metabolizing citalopram, so citalopram levels could rise slightly. The effect is likely small, particularly during short courses.
What this interaction means in plain words
Citalopram and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Possible weak CYP2C19 inhibition by vonoprazan reduces citalopram clearance.
What to do
No dose change is routinely needed. Monitor for increased citalopram adverse effects such as nausea or palpitations, especially in CYP2C19 poor metabolizers.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Citalopram with Vonoprazan?
MediHelp rates the interaction as minor. Citalopram and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vonoprazan may weakly inhibit CYP2C19, one of the main enzymes metabolizing citalopram, so citalopram levels could rise slightly. The effect is likely small, particularly during short courses.
How serious is the interaction between Citalopram and Vonoprazan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor for increased citalopram adverse effects such as nausea or palpitations, especially in CYP2C19 poor metabolizers.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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