Drug interactions
Carbamazepine + Vonoprazan
Severity: Major
Carbamazepine and Vonoprazan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may reduce vonoprazan exposure and diminish acid suppression. This could lead to reduced healing or treatment failure of acid-related disease or H. pylori regimens.
What this interaction means in plain words
Carbamazepine and Vonoprazan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Carbamazepine induces CYP3A4, which is a metabolic pathway for vonoprazan.
What to do
Avoid combining with strong CYP3A4 inducers as advised in labeling. Use an alternative acid suppressant such as a proton pump inhibitor and monitor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
- Armodafinil + Vonoprazan Moderate
Frequently asked questions
Can I take Carbamazepine with Vonoprazan?
MediHelp rates the interaction as major. Carbamazepine and Vonoprazan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine may reduce vonoprazan exposure and diminish acid suppression. This could lead to reduced healing or treatment failure of acid-related disease or H. pylori regimens.
How serious is the interaction between Carbamazepine and Vonoprazan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with strong CYP3A4 inducers as advised in labeling. Use an alternative acid suppressant such as a proton pump inhibitor and monitor response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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