Drug interactions
Atazanavir + Vonoprazan
Severity: Major
Atazanavir and Vonoprazan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan produces profound, sustained acid suppression, which markedly reduces atazanavir solubility and absorption. This may lower atazanavir levels, risking virologic failure and resistance.
What this interaction means in plain words
Atazanavir and Vonoprazan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH decreases dissolution and absorption of pH-dependent atazanavir.
What to do
Avoid concomitant use and consider an antiretroviral not dependent on gastric acidity. If acid suppression is required, use an alternative regimen guided by HIV specialist advice.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
- Armodafinil + Vonoprazan Moderate
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Vonoprazan?
MediHelp rates the interaction as major. Atazanavir and Vonoprazan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vonoprazan produces profound, sustained acid suppression, which markedly reduces atazanavir solubility and absorption. This may lower atazanavir levels, risking virologic failure and resistance.
How serious is the interaction between Atazanavir and Vonoprazan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and consider an antiretroviral not dependent on gastric acidity. If acid suppression is required, use an alternative regimen guided by HIV specialist advice.
What other medicines interact with Vonoprazan?
MediHelp also lists interactions of Vonoprazan with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Vonoprazan page.
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