Drug interactions
Citalopram + Voxelotor
Severity: Moderate
Citalopram and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may raise exposure to CYP3A4 substrates, and citalopram is partly metabolized by this enzyme. The increase in citalopram levels is probably modest, but it could increase QT and serotonergic effects.
What this interaction means in plain words
Citalopram and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 by voxelotor reduces citalopram metabolism.
What to do
Monitor for citalopram adverse effects and consider an ECG in patients with QT risk factors. Reduce the citalopram dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Citalopram with Voxelotor?
MediHelp rates the interaction as moderate. Citalopram and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and may raise exposure to CYP3A4 substrates, and citalopram is partly metabolized by this enzyme. The increase in citalopram levels is probably modest, but it could increase QT and serotonergic effects.
How serious is the interaction between Citalopram and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for citalopram adverse effects and consider an ECG in patients with QT risk factors. Reduce the citalopram dose if adverse effects occur.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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