Drug interactions
Amobarbital + Voxelotor
Severity: Major
Amobarbital and Voxelotor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital can reduce voxelotor exposure through CYP3A4 induction, potentially lessening its effect on hemoglobin polymerization in sickle cell disease.
What this interaction means in plain words
Amobarbital and Voxelotor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by amobarbital increases voxelotor metabolism.
What to do
Avoid coadministration. If it is unavoidable, increase the voxelotor dose per labeling and monitor hemoglobin and clinical response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Voxelotor
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
- Ergotamine + Voxelotor Major
Frequently asked questions
Can I take Amobarbital with Voxelotor?
MediHelp rates the interaction as major. Amobarbital and Voxelotor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital can reduce voxelotor exposure through CYP3A4 induction, potentially lessening its effect on hemoglobin polymerization in sickle cell disease.
How serious is the interaction between Amobarbital and Voxelotor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. If it is unavoidable, increase the voxelotor dose per labeling and monitor hemoglobin and clinical response.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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