Drug interactions
Enzalutamide + Voxelotor
Severity: Major
Enzalutamide and Voxelotor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer that can substantially reduce voxelotor exposure and its effect on hemoglobin. Voxelotor is also a weak CYP3A4 inhibitor, but this has limited relevance to enzalutamide.
What this interaction means in plain words
Enzalutamide and Voxelotor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Voxelotor belongs to Miscellaneous.
Why it happens
Enzalutamide induces CYP3A4, accelerating voxelotor metabolism.
What to do
Avoid concurrent use. If it is unavoidable, increase the voxelotor dose as the labeling recommends and monitor hemoglobin and hemolysis markers.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Ergotamine + Voxelotor Major
Frequently asked questions
Can I take Enzalutamide with Voxelotor?
MediHelp rates the interaction as major. Enzalutamide and Voxelotor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer that can substantially reduce voxelotor exposure and its effect on hemoglobin. Voxelotor is also a weak CYP3A4 inhibitor, but this has limited relevance to enzalutamide.
How serious is the interaction between Enzalutamide and Voxelotor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If it is unavoidable, increase the voxelotor dose as the labeling recommends and monitor hemoglobin and hemolysis markers.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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