Drug interactions
Clemastine + Cyclizine
Severity: Moderate
Clemastine and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedating antihistamines with anticholinergic activity, so combined use increases drowsiness and impairs alertness. Dry mouth, blurred vision and urinary retention are also more likely.
What this interaction means in plain words
Clemastine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Cyclizine belongs to Respiratory.
Why it happens
Additive central H1-receptor antagonism and muscarinic blockade.
What to do
Avoid concurrent use where possible. If needed, counsel on sedation and monitor older patients for confusion and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Clemastine with Cyclizine?
MediHelp rates the interaction as moderate. Clemastine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sedating antihistamines with anticholinergic activity, so combined use increases drowsiness and impairs alertness. Dry mouth, blurred vision and urinary retention are also more likely.
How serious is the interaction between Clemastine and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If needed, counsel on sedation and monitor older patients for confusion and falls.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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