Drug interactions
Clemastine + Gabapentin enacarbil
Severity: Moderate
Clemastine and Gabapentin enacarbil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil is converted to gabapentin, which causes sedation and occasionally respiratory depression. Clemastine adds sedation, increasing drowsiness, dizziness and psychomotor impairment.
What this interaction means in plain words
Clemastine and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive CNS depression through pharmacodynamic synergism.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, particularly in older adults or those with lung disease. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Clemastine with Gabapentin enacarbil?
MediHelp rates the interaction as moderate. Clemastine and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin enacarbil is converted to gabapentin, which causes sedation and occasionally respiratory depression. Clemastine adds sedation, increasing drowsiness, dizziness and psychomotor impairment.
How serious is the interaction between Clemastine and Gabapentin enacarbil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, particularly in older adults or those with lung disease. Advise against driving until the response is known.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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