Drug interactions
Amobarbital + Gabapentin enacarbil
Severity: Major
Amobarbital and Gabapentin enacarbil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a barbiturate with a gabapentinoid can cause additive sedation and respiratory depression. Serious cases are more likely in the elderly and those with lung disease.
What this interaction means in plain words
Amobarbital and Gabapentin enacarbil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS and respiratory depression.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, especially in at-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Amobarbital with Gabapentin enacarbil?
MediHelp rates the interaction as major. Amobarbital and Gabapentin enacarbil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a barbiturate with a gabapentinoid can cause additive sedation and respiratory depression. Serious cases are more likely in the elderly and those with lung disease.
How serious is the interaction between Amobarbital and Gabapentin enacarbil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, especially in at-risk patients.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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