Drug interactions
Clorazepate + Gabapentin enacarbil
Severity: Major
Clorazepate and Gabapentin enacarbil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, and combined use increases the risk of sedation, dizziness and respiratory depression. The risk is greater in older adults, those with lung disease, and with other sedatives or opioids.
What this interaction means in plain words
Clorazepate and Gabapentin enacarbil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clorazepate belongs to Central Nervous System; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression through GABA-A potentiation by clorazepate and gabapentinoid effects on calcium channels.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Avoid adding other CNS depressants and reduce doses in patients with respiratory risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Clorazepate with Gabapentin enacarbil?
MediHelp rates the interaction as major. Clorazepate and Gabapentin enacarbil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause CNS depression, and combined use increases the risk of sedation, dizziness and respiratory depression. The risk is greater in older adults, those with lung disease, and with other sedatives or opioids.
How serious is the interaction between Clorazepate and Gabapentin enacarbil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Avoid adding other CNS depressants and reduce doses in patients with respiratory risk.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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