Drug interactions
Clemastine + Loxapine
Severity: Moderate
Clemastine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating antihistamine with notable anticholinergic activity. With loxapine it can cause marked drowsiness, impaired alertness and additive anticholinergic effects such as constipation, urinary retention and blurred vision.
What this interaction means in plain words
Clemastine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects from H1 antagonism and antipsychotic receptor blockade.
What to do
Warn about sedation and avoid activities needing alertness until tolerance is clear. Consider a second-generation antihistamine and monitor for anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Loxapine?
MediHelp rates the interaction as moderate. Clemastine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating antihistamine with notable anticholinergic activity. With loxapine it can cause marked drowsiness, impaired alertness and additive anticholinergic effects such as constipation, urinary retention and blurred vision.
How serious is the interaction between Clemastine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn about sedation and avoid activities needing alertness until tolerance is clear. Consider a second-generation antihistamine and monitor for anticholinergic effects.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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