Drug interactions
Clemastine + Maprotiline
Severity: Moderate
Clemastine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and have antimuscarinic properties, so using them together can increase drowsiness and slow reaction time. Anticholinergic effects such as dry mouth, blurred vision, constipation and urinary hesitancy may also be additive.
What this interaction means in plain words
Clemastine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive H1 antihistamine sedation and additive anticholinergic activity.
What to do
Counsel on avoiding driving and alcohol, and consider a non-sedating antihistamine. Monitor older patients closely for confusion and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Maprotiline?
MediHelp rates the interaction as moderate. Clemastine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and have antimuscarinic properties, so using them together can increase drowsiness and slow reaction time. Anticholinergic effects such as dry mouth, blurred vision, constipation and urinary hesitancy may also be additive.
How serious is the interaction between Clemastine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on avoiding driving and alcohol, and consider a non-sedating antihistamine. Monitor older patients closely for confusion and urinary retention.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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