Drug interactions
Clemastine + Metaxalone
Severity: Moderate
Clemastine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating first-generation antihistamine. Combined with metaxalone it can increase drowsiness and reduce alertness.
What this interaction means in plain words
Clemastine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1 antagonism and metaxalone sedation.
What to do
Monitor for oversedation, and consider a non-sedating antihistamine. Advise patients to avoid driving while drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Metaxalone?
MediHelp rates the interaction as moderate. Clemastine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating first-generation antihistamine. Combined with metaxalone it can increase drowsiness and reduce alertness.
How serious is the interaction between Clemastine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, and consider a non-sedating antihistamine. Advise patients to avoid driving while drowsy.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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