Drug interactions
Clomiphene + Ospemifene
Severity: Major
Clomiphene and Ospemifene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are selective estrogen receptor modulators with overlapping estrogen agonist and antagonist actions. Combined use has no established benefit and may add to endometrial and thromboembolic risk and unpredictable hormonal effects.
What this interaction means in plain words
Clomiphene and Ospemifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomiphene belongs to Endocrine; Ospemifene belongs to Endocrine.
Why it happens
Competition and additive activity at estrogen receptors.
What to do
Avoid concurrent use; their indications rarely overlap so choose one agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clomiphene
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
- Ospemifene + Rifampicin Major
Frequently asked questions
Can I take Clomiphene with Ospemifene?
MediHelp rates the interaction as major. Clomiphene and Ospemifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are selective estrogen receptor modulators with overlapping estrogen agonist and antagonist actions. Combined use has no established benefit and may add to endometrial and thromboembolic risk and unpredictable hormonal effects.
How serious is the interaction between Clomiphene and Ospemifene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; their indications rarely overlap so choose one agent.
What other medicines interact with Clomiphene?
MediHelp also lists interactions of Clomiphene with, for example, Amlodipine-benazepril. The full list is on the Clomiphene page.
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