Drug interactions
Ospemifene + Raloxifene
Severity: Major
Ospemifene and Raloxifene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are estrogen receptor modulators that act on the same receptors and carry similar risks, including venous thromboembolism. Taking them together adds no proven benefit and may increase thromboembolic risk and cause unpredictable receptor effects.
What this interaction means in plain words
Ospemifene and Raloxifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ospemifene belongs to Endocrine; Raloxifene belongs to Endocrine.
Why it happens
Duplicate selective estrogen receptor modulator activity with additive pharmacodynamic effects, including prothrombotic effects.
What to do
Avoid using the two agents together and choose one based on the indication (osteoporosis versus dyspareunia). If switching, stop one before starting the other.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Raloxifene
- Cholestyramine + Raloxifene Major
- Apalutamide + Raloxifene Moderate
- Levothyroxine + Raloxifene Moderate
- Famciclovir + Raloxifene Minor
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Rifampicin Major
Frequently asked questions
Can I take Ospemifene with Raloxifene?
MediHelp rates the interaction as major. Ospemifene and Raloxifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are estrogen receptor modulators that act on the same receptors and carry similar risks, including venous thromboembolism. Taking them together adds no proven benefit and may increase thromboembolic risk and cause unpredictable receptor effects.
How serious is the interaction between Ospemifene and Raloxifene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two agents together and choose one based on the indication (osteoporosis versus dyspareunia). If switching, stop one before starting the other.
What other medicines interact with Raloxifene?
MediHelp also lists interactions of Raloxifene with, for example, Cholestyramine, Apalutamide, Levothyroxine. The full list is on the Raloxifene page.
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