Drug interactions
Clonazepam + Cyclobenzaprine
Severity: Moderate
Clonazepam and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so combining them can cause pronounced drowsiness, dizziness, slowed reactions and falls. Risk is greater in older adults and with alcohol or other sedatives.
What this interaction means in plain words
Clonazepam and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Cyclobenzaprine belongs to Musculoskeletal.
Why it happens
Additive CNS depression via GABA-A potentiation and central antihistaminic/anticholinergic effects.
What to do
Use the lowest effective doses for the shortest duration and monitor sedation and fall risk. Counsel against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Clonazepam and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so combining them can cause pronounced drowsiness, dizziness, slowed reactions and falls. Risk is greater in older adults and with alcohol or other sedatives.
How serious is the interaction between Clonazepam and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor sedation and fall risk. Counsel against alcohol and driving.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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