Drug interactions
Clonazepam + Cyproheptadine
Severity: Moderate
Clonazepam and Cyproheptadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating antihistamine with a benzodiazepine can deepen sedation and impair psychomotor performance and memory. The risk is greater in older adults and with alcohol.
What this interaction means in plain words
Clonazepam and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Cyproheptadine belongs to Respiratory.
Why it happens
Additive CNS depression via H1 blockade and GABA-A potentiation.
What to do
Monitor for excessive sedation and falls, and consider reducing doses. Advise avoidance of driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Cyproheptadine?
MediHelp rates the interaction as moderate. Clonazepam and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sedating antihistamine with a benzodiazepine can deepen sedation and impair psychomotor performance and memory. The risk is greater in older adults and with alcohol.
How serious is the interaction between Clonazepam and Cyproheptadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and falls, and consider reducing doses. Advise avoidance of driving and alcohol.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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