Drug interactions
Clonazepam + Istradefylline
Severity: Moderate
Clonazepam and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At the higher dose of istradefylline (40 mg/day), exposure to CYP3A4 substrates can rise, which may increase clonazepam levels and its sedative effects. At 20 mg/day this effect was not seen.
What this interaction means in plain words
Clonazepam and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses inhibits CYP3A4, reducing clonazepam metabolism.
What to do
Monitor for increased sedation and ataxia when istradefylline 40 mg/day is used, and reduce the clonazepam dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Clonazepam with Istradefylline?
MediHelp rates the interaction as moderate. Clonazepam and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At the higher dose of istradefylline (40 mg/day), exposure to CYP3A4 substrates can rise, which may increase clonazepam levels and its sedative effects. At 20 mg/day this effect was not seen.
How serious is the interaction between Clonazepam and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and ataxia when istradefylline 40 mg/day is used, and reduce the clonazepam dose if needed.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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