Drug interactions
Clonazepam + Ivosidenib
Severity: Moderate
Clonazepam and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower clonazepam concentrations, potentially reducing seizure or anxiety control. The effect develops gradually with continued ivosidenib.
What this interaction means in plain words
Clonazepam and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing clonazepam metabolism.
What to do
Monitor for loss of clonazepam efficacy, especially seizure control, and adjust the dose if needed. Reassess the dose when ivosidenib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Clonazepam with Ivosidenib?
MediHelp rates the interaction as moderate. Clonazepam and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower clonazepam concentrations, potentially reducing seizure or anxiety control. The effect develops gradually with continued ivosidenib.
How serious is the interaction between Clonazepam and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of clonazepam efficacy, especially seizure control, and adjust the dose if needed. Reassess the dose when ivosidenib is discontinued.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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