Drug interactions
Clonazepam + Lofexidine
Severity: Moderate
Clonazepam and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine can cause sedation, hypotension and bradycardia, and clonazepam adds to the sedation. Dizziness and falls may result, especially at the start of treatment.
What this interaction means in plain words
Clonazepam and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Lofexidine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and central alpha-2 adrenergic agonism, with additive hypotension.
What to do
Monitor blood pressure, heart rate and sedation, and counsel patients about rising slowly. Reduce the dose if symptomatic hypotension or oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Clonazepam with Lofexidine?
MediHelp rates the interaction as moderate. Clonazepam and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine can cause sedation, hypotension and bradycardia, and clonazepam adds to the sedation. Dizziness and falls may result, especially at the start of treatment.
How serious is the interaction between Clonazepam and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation, and counsel patients about rising slowly. Reduce the dose if symptomatic hypotension or oversedation occurs.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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