Drug interactions
Clonazepam + Suvorexant
Severity: Moderate
Clonazepam and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combining them can add to drowsiness, slowed reaction time and next-day impairment. Falls and impaired driving are the main practical concerns.
What this interaction means in plain words
Clonazepam and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation by clonazepam and orexin receptor antagonism by suvorexant.
What to do
Use the lowest effective dose of each drug and consider dose reduction of suvorexant. Counsel patients about daytime impairment and avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Suvorexant
Frequently asked questions
Can I take Clonazepam with Suvorexant?
MediHelp rates the interaction as moderate. Clonazepam and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combining them can add to drowsiness, slowed reaction time and next-day impairment. Falls and impaired driving are the main practical concerns.
How serious is the interaction between Clonazepam and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of each drug and consider dose reduction of suvorexant. Counsel patients about daytime impairment and avoid driving until the response is known.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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